Posts Tagged ‘cannabinoid’
UK Department of Health Has Neither Requested Nor Received Any Advice On Medicinal Cannabis.
This is the astonishing reality of the way the UK government is responding to the national outcry for access to cannabis as medicine. They are doing absolutely nothing.
Across the world a revolution is taking place as more and more jurisdictions are introducing legal access to medical cannabis. Medical professionals and patients alike are realising the huge benefits to be gained from re-opening access to this most valuable of medicines. Scientific research is proving beyond doubt that cannabis is a safe and effective medicine for a wide range of conditions. Many pharmaceutical companies are investigating different cannabinoids, extracts and therapies. Most of all, citizens are demanding access to a medicine that has been denied to them for no good reason and that can improve, even save the lives of people of all ages, from the baby with severe epilepsy to the grandparent suffering the effects of aging, even dementia. Cannabis can help improve and maintain good health in all of us.
Yet the UK government is not considering the evidence. Despite even a year long Parliamentary inquiry which recommended permitting access, the Department of Health has not considered nor even asked for any expert advice. My Freedom of Information request has established this beyond doubt. See here: https://www.whatdotheyknow.com/request/395319/response/965315/attach/html/2/1078680%20Reynolds.pdf.html
I have been pressing my MP, Sir Oliver Letwin, on this issue ever since I became his constituent two years ago. Early on he was an extremely powerful cabinet minster, generally recognised as number three in the government after David Cameron and George Osborne but he was swiftly sacked when Theresa May became prime minister. He has already announced he will not stand for re-election to the next Parliament.
To be fair, Oliver has always listened to me politely and attentively. We have met on about half a dozen occasions and we frequently exchange emails. He has been more responsive to me than I had hoped and to begin with he told me he was investigating what was happening in government about the subject. His answer was that the evidence has been considered, expert advisors have been consulted and ministers have concluded that there is not a good case for reform.
I have pressed him again and again, shown him reams of evidence, shared stories with him from across the world, both of scientific research and patient testimonies. While always courteous towards me he has remained resolutely opposed. I could have given up long ago. Indeed, when I asked him why can’t we simply leave it to the professional judgement of doctors whether to prescribe it or not, he gave me an answer straight out of a ‘Yes Minster’ script. He said: “But then they would prescribe it.”
At the beginning of this year I asked him once again for assistance in putting me before a minister to advance my case. He replied:
“We have discussed this issue before, but I am happy to set out the reason why I will not support your proposals. The Department of Health have, as you know, considered this issue, have taken advice on it from their professional public health advisors, and have concluded that the gains in healthcare arising from the legalisation of medicinal cannabis (as opposed to cannabinoids) would not be sufficiently great to outweigh the risk of abuse.”
It seems that, at best, Sir Oliver is mistaken. I have written to him again asking for comments on the FOI response.
Whatever reply I now receive, I urge everyone to get on to their MP about this. It is a scandal. There can be no doubt that it is irresponsible and negligent that the Department of Health is so clearly failing in its duty to the country. That’s not to say how very cruel and inhumane this failure is or how much money legal medical cannabis could save the NHS. Jeremy Hunt, the Secretary of State for Health, must be called to account for this.
Top Jersey Doctor Misinforms and Misleads On Medicinal Cannabis.
Dr Nigel Minihane is the head of Jersey Primary Care Trust which represents all GPs on the island. Recently he contributed supposedly ‘expert opinion’ to an article in the Jersey Evening Post about someone who had been juicing raw cannabis for therapeutic reasons. His comments demonstrate an ignorance and lack of knowledge which is unacceptable in a doctor in such a senior position. In conjunction with CLEAR members in Jersey, we have submitted a formal complaint.
Dear Sirs,
On behalf of our members in Jersey, we wish to bring a complaint of misconduct against Dr. Nigel Minihane concerning comments attributed to him and published in the Jersey Evening Post on 13th February 2016.
The article in question is attached to this email. The passage we are concerned about is at the very end of the article where Dr Minihane gives false information about a recent drug trial in France which resulted in one death and several people suffered brain damage.
The trial to which Dr Minhane refers was not “of a cannabinoid substance”, it was of an FAAH inhibitor, known as BIA 10-2474. This drug is designed to inhibit the natural degradation of endocannabinoids, leading, it was hoped, to pain relief through modulation of the CB receptor network. It was therefore neither a cannabinoid substance nor cannabis. See: http://www.nature.com/news/scientists-in-the-dark-after-french-clinical-trial-proves-fatal-1.19189
Dr Minihane’s words were therefore inaccurate and misleading and contribute to the prejudice and misunderstanding around the use of cannabis and cannabinoids as medicine. Dr Minihane is, of course, entitled to his opinion but based on his other comments in the article he is clearly very poorly informed on the subject. There is a vast amount of peer reviewed, published evidence which supports the safety and efficacy of cannabis and cannabinoids as medicine. See attached paper ‘Medicinal Cannabis: The Evidence’. Furthermore, it is well established in the evidence that cannabis is physically addictive, with about 9% of regular users developing dependence which is characterised by physical withdrawal symptoms including insomnia, lack of appetite and headache.
We understand that Dr Minihane is head of the Jersey Primary Care Trust and the Jersey Evening Post will have asked him to provide an expert opinion. The information he provided was inaccurate, misleading and reckless. In our view it falls well below the professional standard that one is entitled to expect from any doctor. It is woefully inadequate in the case of a doctor in such a senior position who holds himself out as an expert yet communicates false information to the public through the media.
We would be grateful if you would consider this complaint at your earliest opportunity. We are able to provide oral evidence in support and to suggest witnesses resident in Jersey who endure unnecessary pain and suffering due to medicinal conditions that coud be treated by cannabis if the PCT was properly assessing and considering the evidence.
Yours faithfully
Peter Reynolds
President
This Is The Future Of Cannabis. For Medicine, Nutrition And Pleasure.
One of these vape pens contains Blue Dream sativa cannabis oil, 91% THC, the other is Hindu Kush indica cannabis oil, 85% THC and the spare cartridge has the dregs of some New York City Diesel sativa, 85% THC. You can’t tell which is which to look at them but each has a distinctive flavour and effect. They’re not completely odour free but almost.
This is the future of cannabis as a consumer product. It is cleaner, neater, handier, healthier and better for you than raw herbal cannabis. Most importantly, for medicinal applications, it homogenises all the compounds into an oil of consistent quality and content meaning that dosage and effect at last becomes predictable and reliable.
I have been investigating this theory for some time but my recent trip to Colorado enabled me to conduct some practical experiments and more thoroughly understand how this idea can work. I am now convinced that this is the way forward for the cannabis industry. Once we achieve legalisation in the UK, which is inevitable, probably in about five years, these pens are how cannabis will become available as a consumer product on the high street. They are also how medicinal cannabis will be dispensed. Your doctor’s prescription will be fulfilled by a cartridge with the appropriate blend of cannabinoids which you screw onto your battery and use immediately. Batteries will also be supplied on prescription, in the same way that syringes or blood glucose meters are for diabetics.
In Colorado dispensaries these pens are already available in a choice of strains and blends. Currently, the popular products contain 250 mg of THC in a blend of cannabis oil and propylene glycol (PG), just as e-cigs contain a nicotine oil and PG.
Alternatively, you can buy the oil of your choice and fill the cartridges yourself. This is undoubtedly the way to do it and a wide choice of oils is available, made by CO2 and solvent extraction processes. The Farm, my favourite dispensary in Boulder, is already supplying cannabinoid blends such as a 60% CBD, 12% THC, 4% CBN product which is clearly for medicinal use. I have no doubt that soon we will see a Charlotte’s Web product and Sativex-like blends with equal ratios of THC:CBD. Other, more sophisticated blends of other cannabinoids and probably terpenes will soon follow.
However, I am certain that some propylene glycol is a good thing. The oil vapes much better when diluted and PG is nothing to worry about, it is in many health, cosmetic and food products. It has many uses. It’s a solvent, humectant (keeps things moist), preservative and it helps absorption of some products. It is non-toxic.
There is further development work to be done. I believe there is a ‘sweet spot’ for the correct amount of PG, probably around 20%. I also think the battery and cartridges can be improved, particularly for medical use. Once this is achieved, a product like this with perhaps a 60:40 THC:CBD ratio should form the basis of an application to the Medicines and Health products Regulatory Agency (MHRA) for a marketing authorisation. It will knock Sativex into a cocked hat. In fact, if GW Pharma aren’t investigating this already then they are failing in their duty to shareholders. I shall certainly be doing all I can to research and facilitate the funding to bring such a product to market.
Yes, this is the future of cannabis. Imagine the packaging, marketing and merchandising opportunities for the recreational market. Understand the overwhelming benefits of this as medicine against the raw, herbal product. Yes, I know some will object and the tired old hippy luddites will say it’s a sell out and many more Big Pharma conspiracy theories will emerge but this is the future. Remember you heard it here first.
There Is No Scientific Evidence That Cannabis Cures Cancer In Humans – Yet.
Most of the evidence concerning cannabis and cancer is in vitro or in vivo (animals). There is virtually none in humans, only human cell lines in petri dishes. There is no evidence of a curative effect. The only clinical trial was purified THC fed directly into glioma brain tumours in nine patients. Eight showed some benefit but all were dead within one year.
The evidence almost certainly will come but it does not yet exist and may require specific extracts, concentrates or other processes to produce reliable, consistent, clinical results.
This is a pre-publication extract from ‘Medicinal Cannabis:The Evidence’, the most comprehensive and up to date review of the evidence on medicinal cannabis, shortly to be published by CLEAR.
Studies And Clinical Trials
Cancer
The anti cancer properties of THC, CBD, CBG and other cannabinoids are well established. Scientists have been investigating them since the early 1970s and more than 1100 papers on cannabinoids and cancer have been published. (42)
It is also well established that cannabis helps with the side effects of cancer treatments, particularly nausea and lack of appetite. (43,44,45,46)
Cannabis may also help alleviate anxiety, depression, insomnia and mood disorders in cancer patients. However, some patients may find exactly the opposite results (47)
A very large quantity of anecdotal reports detail remarkable results with cannabis oil on many different forms of cancer. (48) One of the most important properties of cannabis as a cancer therapy is that it is non-toxic and even if little therapeutic effect is achieved, it causes little harm.
On balance, while there is good evidence of anti cancer properties in vitro (human cell lines) and in vivo (animal) studies, there is little evidence of actual results in humans except in the treatment of basal cell carcinoma (49). However, few would disagree that the palliative value of cannabis is of great benefit to many cancer patients. (50)
Clinical trials are underway on cancer pain (51) and the treatment of glioma brain cancer (52).
These selected studies indicate the evidence currently available.
Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581 (53)
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html (54)
Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339 (55)
Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long (56)
The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext (57)
Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349 (58)
Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283 (59)
Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/ (60)
Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs (61)
Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20 (62)
Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/ (63)
The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955 (64)
References
42. PubMed search term ‘cannabinoid cancer’ http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer
43. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5
44. Cannabinoids in medicine: A review of their therapeutic potential. JEthPharm, 2006. http://www.ww.ufcw770.org/sites/all/themes/danland/files/CannabinoidsMedMetaAnalysis06.pdf
45. Review on clinical studies with cannabis and cannabinoids 2005-2009. IACM 2010. http://www.cannabis-med.org/data/pdf/en_2010_01_special.pdf
46. Medical marijuana for cancer. CA: A Cancer Journal for Clinicians, 2014. http://onlinelibrary.wiley.com/doi/10.3322/caac.21260/abstract
47. Cannabis and Cannabinoids. National Cancer Institute, 2014 http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5
48. Cannabis Oil Testimonials. Cure Your Own Cancer, 2014. http://www.cureyourowncancer.org/testimonials.html
49. Physician’s documentation confirms successful treatment of basal cell carcinoma resulted from the application of a topical cannabis extract. Cannabis Science, 2011. http://www.cannabisscience.com/2011/499-cannabis-science-provides-physician-s-documentation-that-confirms-successful-treatment-of-skin-cancer
50. Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity. AM J HOSP PALLIAT CARE, 2011. http://ajh.sagepub.com/content/28/5/297
51. Third phase III Sativex cancer pain trial commences http://www.gwpharm.com/Third%20phase%20III%20Sativex%20cancer%20pain%20trial%20commences.aspx
52. GW Pharmaceuticals Commences Phase 1b/2a Clinical Trial for the Treatment of Glioblastoma Multiforme (GBM) http://is.gd/Wac81a
53. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16042581
54. A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme, British Journal of Cancer, 2006 http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html
55. Cannabinoids for Cancer Treatment: Progress and Promise. Cancer Res. 2008. http://cancerres.aacrjournals.org/content/68/2/339
56. Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy. Mol Cancer Ther., 2011. http://mct.aacrjournals.org/content/10/7/1161.long
57. The intersection between cannabis and cancer in the United States. CROH, 2011. http://www.croh-online.com/article/S1040-8428(11)00231-9/fulltext
58. Cannabinoids: a new hope for breast cancer therapy? Cancer Treat Rev. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22776349
59. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22555283
60. Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation. Case Rep Oncol. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/
61. Non-hallucinogenic cannabinoids are effective anti-cancer drugs. Anticancer Research, 2013. http://www.sgul.ac.uk/news/news/study-shows-non-hallucinogenic-cannabinoids-are-effective-anti-cancer-drugs
62. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013. http://www.ncbi.nlm.nih.gov/pubmed/22506672%20
63. Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK, 2014. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/
64. The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol.Cancer.Ther. 2014. http://mct.aacrjournals.org/content/13/12/2955
The Miracle Of Healing.
Whatever your religious belief, if any, the stories of Christ’s miraculous healing have persisted for more than 2,000 years. Such legends develop from oral history and we can never be certain how much is truth, how much is myth and what is a combination of both. Those of faith carry their own certainty in their soul. What is remarkable is the coincidence of several factors that together strongly suggest that the Holy anointing oil used by Christ, his disciples and other healers of the time may have contained cannabis as one of its major active ingredients.
The recipe for Holy anointing oil appeared in ancient Hebrew texts and, unsurprisingly, there are conflicting views about translation.
‘Kaneh-bosm’ ‘qneh-bism’, etc, etc are variants on a word used in ancient Hebrew texts which can be interpreted, credibly, as cannabis. So can ‘calamus’ or ‘sweet calamus’. Different sources seem to use the words interchangeably. However, if you add in the other factors, the healing, the region, its flora, the archaeological evidence and the well established use of cannabis in the region at the time then there is a very, very strong hypothesis. To anyone who understands the miraculous healing properties of cannabis, now explained by modern science it seems common sense.
One CLEAR member, David Boylan, wrote these beautiful words about his faith and cannabis:
“God must have spent a lot of time and effort to produce your endocannabinoid system.
An incredibly complex neurological system in everyone, with the sole purpose of being a receptor for cannabinoids. That must have taken our creator a lot of thought and effort to design…
Trillions of cells devoted to receiving THC and other compounds found ONLY in cannabis. God also ensured that this plant shows up all over the world and grows all around man where ever he looked… So God took all that care for what?
Did God say – “Let there be cannabis”? Then said “Let man have an endocannabinoid system which is stimulated only by cannabis”?
Then did he say…”And now let man get an £80 fixed penalty ticket if man uses it?? Did he say that? NO! Makes no sense, and there is nowhere in the bible I can find that.
I can’t see why Christians don’t have a problem with the government making Gods work illegal? Who are the government to ban God’s work?
It must have been God’s intent for us to at least experiment with cannabis.
That is my only logical conclusion, knowing the facts about the endocannabinoid system. The only conclusion I can make on a creator and pot.”
References:
http://www.freeanointing.org/cannabis_in_the_holy_oil.htm
http://patients4medicalmarijuana.wordpress.com/marijuana-info/marijuana-in-the-bible/jesus-cannabis/
http://cannacentral.com/news/cannabis-christianity-and-the-great-kaneh-bosm-debate-did-jesus-use-pot/
Synthetic Cannabinoids. A Nasty Business, By Nasty People, With Nasty Results.
Cannabinoids are powerful substances. They are fundamental to life. With that power comes danger. Modern science and chemistry allows unscrupulous businessmen to exploit and endanger young people as they follow the perfectly natural path of all youngsters – to experiment and to get “high”.
In mammals, birds, reptiles and fish, the endocannabinoid system regulates all aspects of physical and mental health. Evolution, Mother Nature, God, Science – whatever name you assign to it – has endowed the cannabis plant as the only natural source of cannabinoids outside the body. Self-evidently, we are in a chicken and egg dilemma here about names and terminology but the facts remain the same, cannabinoids are vital substances. The cannabis plant exists in a symbiotic relationship with mankind. No wonder that some call it sacred.
The great immoral evil that is prohibition seeks to deny access to cannabis. So, in our modern, technological world, inevitably, people find a way to circumvent the law. This was the birth of “legal highs”, the creation of “analogues” or slight molecular variations of delta-9-tetrahydrocannibinol (THC), notorious as the ingredient in cannabis that gets you “high”. In fact, the benefits of cannabis are much more complex than that. It is the interaction of around 100 cannabinoids in the plant together with terpines, flavonoids and other compounds that produce the delightful and therapeutic effects.
The effect of synthetic cannabinoids – “Spice” was the biggest brand name ever – is vile. It is really, truly horrible. It has none of the inherent, natural, protective balance of real cannabis. It causes paranoia, anxiety, fear, delusions, all the symptoms that describe psychosis, the term that has been used to demonise cannabis which, in its natural form, is actually very safe and contains anti-psychotic agents. Worse than that, Spice can lead to elevated blood pressure, heart palpitations, seizures and vomiting. As well as the lack of natural, counterbalancing ingredients, it is also believed to bind more strongly to the cannabinoid receptors, increasing the duration and potency of its effects.
In Britain, the centre of the synthetic cannabinoid business is Totnes, an apparently sleepy market town in Devon. In fact, it is an important hub of the synthetic cannabinoid business in Europe and worldwide. Here, in a grubby warehouse, on a run down industrial estate, completely untested chemical compounds are imported from China, mixed with other ingredients of dubious source and then distributed around the Britain and the world, largely to be sold to young people and children, completely outside the control, moral or legal regulation of any responsibility.
If Shaun Sawyer, the chief constable of Devon and Cornwall wants to do something effective to protect young people, instead of breaking down the doors of people growing a few cannabis plants he should be checking out the contents of this warehouse in Totnes. It is a combination of laziness and ignorance that the police aren’t dealing with this. Spice and other synthetic cannabinoids are far, far more dangerous to our young people and our communities than the natural and generally benign cannabis plant.
Spice and other synthetic cannabinoids are usually dried herbs or plant material that has been sprayed with cannabinoid(s) and marketed as a smoking material. Often the plant material itself has some sort of psychoactive effect. These include blue water lily (Nymphaea caerulea), dwarf skullcap (Scutellaria nana), Maconha brava (Zornia latifolia or Z. diphylla), Siberian motherwort (Leonurus sibiricus), Indian warrior (Pedicularis densiflora) and lion’s tail (Leonotis leonuru). Large amounts of Vitamin E have also been found in some samples, possibly to mask detection of the cannabinoids. The cannabinoids themselves are usually JWH-018, JWH-073, JWH-200, CP-47,497, HU-210 and cannabicyclohexanol. They might be used individually or in any ratio or combination that is convenient or profitable.
From 23rd December 2009, these known ingredients of Spice were prohibited and are now “controlled” under the Misuse of Drugs Act 1971 as if they are cannabis. However, they are very difficult to detect and many more synthetic cannabinoids have been developed. In Totnes there may be a large amount of left over Spice, re-packaged as something else, possibly even mixed with new synthetics which this “Mr Big” has formulated for him by his expert chemist who he told me is based in Austria. Who knows what these products contain? Mr Big and the Austrian chemist engage in frequent email correspondence and samples are sent back and forth as ever more effective attempts are made to evade the law and produce stronger and more profitable chemicals.
A year or so ago I was invited inside this warehouse myself and it opened my eyes to the extremes that some people are prepared to go to make a fast buck. It is dark, dank and clammy. It reeks of slightly rotten or putrid contents. There are boxes and crates spread in no apparent order everywhere. There are large envelopes and plastic containers on shelves containing indeterminate substances that look like dried mushrooms, herbs and plant material. There are also unlabelled powders and pills and, surprisingly for something that is now supposed to be against the law to possess or sell, large quantities of packets that are labelled “Spice”, although what they actually contain is uncertain.
Mr Big is surrounded by a small group of sycophants, some work in his warehouse, some are controlled by gifts and “entertainment”. Downstairs in the dingy warehouse groups of people sit around smoking.
Upstairs in the office is even more worrying. There’s everything you would expect at a thriving mail order business. People working on computers, answering telephones, packing orders and yet more strange substances and distinctly dodgy looking products. I am shown a tea caddy-like container, covered in Chinese decoration and writing. I’m told it is the very latest synthetic cannabinoid imported from China. It’s a fine white powder that glistens slightly. Then I’m introduced to the manufacturing process.
A large red “Kitchen Aid” food mixer, the sort you would find in a professional kitchen, is taken off the shelf and Mr Big produces a football sized lump of squidgy, black, supposedly inert, base material. Yes, it looks just like squidgy, black hash but what exactly it contains I have no idea and neither, I should think, does Mr Big. Into the mixing bowl goes a generous handful of this gunk and then the cannabinoid is sprinkled over it. There’s no measurement or calculation or care involved . It’s entirely haphazard and, it has to be said, reckless. The mixer is cranked up to maximum and left to do its work with just one more slug of the white powder for luck. Soon it will be cut into small portions and distributed through head shops and by mail order for unsuspecting people to try.
Yes, I tried it myself. It was horrendous. I am a very experienced cannabis user of over 40 years standing. I’ve tried and enjoyed the strongest varieties, be it Nepalese, Afghan or Pakistani hash, concentrated oil, Thai sticks, the finest medicinal product from Bedrocan in Holland and MMJ dispensaries in the USA. Nothing could have prepared me for the potency and horrible effect of this Totnes poison.
I crumbled a very small amount into my favourite metal pipe, lit it and took a very gentle pull, just enough to get it burning. Within moments I had the most powerful and unpleasant sensation. Every negative, nasty and unwanted effect that I’ve experienced from anything cannabis related was there. Previously, the only bad effects I’ve had from the real thing are when I’ve eaten too much but this was much worse than that. I was instantly on edge, feeling slightly panicky and breathing very quickly. It took fifteen minutes to wear off and the rest of the small sample that Mr Big had given me went straight in the bin.
So what’s the answer to this? Ban it? Lock up Mr Big and throw away the key?
Not at all. Prohibition is a dangerous and irresponsible policy that always causes more harm than it prevents. Remember, Spice is already banned but it hasn’t made any difference to Mr Big and he probably doesn’t even know himself which products in his sordid inventory are allowed and which aren’t. It would probably keep the local drug testing laboratory busy for a year before they manage to go through them all.
These synthetic cannabinoids and all “legal highs” whether or not they’ve yet been banned, are the product of prohibition. They would not exist, nor pose any significant problem, were it not for the ludicrous, self-defeating and harmful policy followed by the British government and other misguided administrations all over the world.
Mr Big and his Austrian chemist will be happy to continue designing new chemicals to sell to our children and there are plenty of unscrupulous Chinese manufacturers who will service their evil trade.
The only answer is to regulate, to introduce a system of licensing, age restrictions and consumer protection. It won’t eliminate the problem entirely but at least it will give us some degree of control, because prohibition provides none.
Mr Big doesn’t give a damn. Although he has a family of his own including small children, all he is concerned with are the hundreds of thousands of pounds he has made by turning Totnes into a worldwide centre for his disgusting trade. We must take responsibility, regulate, control and protect and in due course, Mr Big will get what’s coming to him.
I am pleased to announce that CLEAR will be launching an information campaign about the dangers of synthetic cannabinoids.
The ultimate answer is to end the prohibition of cannabis.
The Future Of Cannabis In Britain Is CLEAR
Last Thursday, 24th March 2011, the latest ballot of the membership of the Legalise Cannabis Alliance closed. By a two-thirds to one-third majority the members voted to adopt a new constitution and to change the party’s name. From that moment on we are known as Cannabis Law Reform or CLEAR.
We have moved away from the use of the word “legalise” because it is interpreted as meaning a free for all. It scares people, particularly politicians and the media and we, as a party, now understand that these are the people we need to influence if we are to advance our cause.
We have also refined and sharpened our aims and objectives. They are now simple, direct and clear:
- To end the prohibition of cannabis.
- To promote as a matter of urgency and compassion the prescription of medicinal cannabis by doctors.
- To introduce a system of regulation for the production and supply of cannabis based on facts and evidence.
- To encourage the production and use of industrial hemp.
- To educate and inform about the uses and benefits of cannabis.
Medicinal cannabis is our spearhead. We seek an end to prohibition for everyone but we demand immediate provision for those who need cannabis as medicine. It is an obscene and evil shame on our nation that so many who suffer are in fear of arrest and prison for using a medicine that transforms their lives.
We will build a new and effective brand and campaign. We are reasonable, responsible, respectable members of society from all walks of life and professions. We are discriminated against by an irrational and absurd policy. Cannabis is a wonderful thing. It is relatively harmless but it is a psychoactive substance and needs to be respected. It’s medicinal value is unparalleled but it also offers wonderful recreational, spiritual and creative nourishment. The relatively young science of cannabinoids now explains why cannabis has been treasured and used by mankind since the dawn of time. Prohibition is a ridiculous policy. The truth about cannabis is clear.
We intend to build a substantial membership. Annual subscriptions have been cut to £5.00 and for concessions £1.00. We ask everyone to make a payment of £10 towards campaign funding but money will not be an obstacle to anyone joining. Please show your support for our campaign and join CLEAR. Within the next few days we will launch a membership drive with the simplest way to sign up being payment by text message.
We will be fielding candidates in council and parliamentary elections all over the UK. We do not expect to win many seats but we intend our campaign to be given the respect and attention it deserves. We will seek electoral pacts with other parties who are prepared to sign up to our aims. If you would like to stand as a candidate, please get in touch. We also need voluntary workers all over the country.
We have exciting campaigns on the way that communicate the scientific truth about cannabis and demolish the scare stories and prejudice that is so widespread. We will never let another ridiculous tabloid story pass without challenging it. We will not allow our political leaders to get away with untruths and propaganda without calling them to account.
We will campaign for an end to the ludicrous waste of law enforcement resources on cannabis and for a regulated system of production that will exclude organised crime and the evils of violence and human trafficking that prohibition causes. We will educate users about cannabinoid content, different strains, varieties and methods of use. We will promote regulation to ensure quality, safety and restriction of sales to adults only.
We already have solid data that proves a tax and regulate regime in Britain would produce a net gain to the economy of at least £6 billion per annum, freeing up police to concentrate on real crime and massively reducing the harms caused by prohibition.
Despite the fact that most people in Britain have used cannabis to no ill effect and that between two and ten million people have it as a regular part of their lives, the cannabis campaign has failed to make any real progress. Now is when that changes. The future of cannabis in Britain is CLEAR.
We will release more details about our campaign in the near future.
The truth about cannabis is CLEAR.
Legal Opportunities For Medicinal Cannabis Users
Recent developments mean that there are new opportunities to challenge the prohibition of cannabis as medicine. Now I am not a lawyer, so these ideas should be carefully discussed with your legal advisors before you even consider pursuing any of them. I may be wrong about the correct procedure, process or terminology. I am highlighting opportunities that I have identified, based on my personal experience and knowledge. Qualified legal advice is essential.
The British government’s current position on medicinal cannabis is absurd and irrational. As I understand it, those are exactly the criteria for which the process of judicial review is intended. That is one route. Another, more risky opportunity arises if you are facing prosecution or have been convicted of an offence of possession, cultivation or production. There are ideas here which you may want to consider as a defence or an appeal. However, please be very careful. If things go wrong, advancing such arguments might result in a heavier sentence, such is the cruel, oppressive and iniquitous intent of current government policy.
The Home Office is simply dishonest in its current stance saying that there “are no medicinal benefits” from cannabis. James Brokenshire, the drugs minister, cannot hide behind a lack of knowledge so he looks either more stupid or dishonest every day. David Cameron made the most dreadful, disingenuous comment about medicinal use in his Al Jazeera World View YouTube interview last week. See here. He said “That is a matter for the science and medical authorities to determine and they are free to make independent determinations about that.” That, of course, is absolute rot and Cameron should be ashamed of himself for such misinformation.
Obtain A Doctor’s Prescription For Medicinal Cannabis
There is nothing to prevent your British doctor from prescribing medicinal cannabis for you if he/she believes it is appropriate. Bedrocan BV is the official contractor to the Dutch government for the production of medicinal cannabis. Go to its website here and you will discover it has a range of products offering different proportions of cannabinoids and terpenoids for different conditions. Prescribing information is available for your doctor in exactly the same way as any other drug. All he/she has to do is select the product and write out a prescription in the normal way. Your doctor can’t get in trouble for this. There is nothing improper or unethical about it, but it is, of course, your doctor’s decision whether to do so or not.
If your doctor isn’t prepared to help, the next best thing is to go to a doctor in Holland, Belgium, Germany, Spain or Italy, all countries where medicinal cannabis is regularly prescribed. In theory, you should be able to see a doctor in another EU country under reciprocal healthcare arrangements but if you can afford it, it may be simpler to go privately.
Another option is to go to one of the 15 US states that permit medical marijuana and obtain a doctor’s recommendation.
Once you have your prescription, you need to apply to the Home Office for a personal import licence to bring your medicine in from Holland. The licensing section on the Home Office website is here. If you obtain a licence you will also need to go through a similar process with the Dutch Bureau voor Medicinale Cannabis to obtain an export licence. The correct section of its website is here.
Of course, the reality is that the Home Office is not going to grant you a licence. You can then pursue the matter through your MP who should make representations to the minister on your behalf. You are then at the point to make an application for judical review of the Home Office’s decision.
Challenge The Government’s Interpretation Of The Schengen Agreement
The Schengen Agreement provides protection for travellers to carry their medicine with them within the EU. The crucial factor is your country of residence. See here for detailed information. Although there is no precise definition of residency, if you are resident in an EU country where medicinal cannabis is permitted, then you may bring your medicine into Britain and, believe it or not, there is no restriction on your use of it. You would be perfectly entitled to sit on the steps of Scotland Yard or even the Home Office’s Marsham Street HQ and smoke a spliff. However, if you are a UK resident, even if you have obtained your medicine on prescription abroad, you are not protected. This is clearly discriminatory under EU law and could be challenged in court. I’m not certain whether you would apply to a British court or to the European court but your solicitor would advise you on this.
Defence Or Appeal On The Grounds Of Medical Necessity
The Appeal Court disallowed a defence of medical necessity back in 2005. A petition to the House Of Lords Judicial Committee and to the European Court Of Human Rights was dismissed without any reasons given. I understand that the Appeal Court’s reasoning was that there were no proven medicinal benefits of cannabis. However, things have changed enormously since then. The MHRA approval of Sativex and the Home Office’s issue of a general licence for it are conclusive proof of medicinal value. Whatever misinformation the Home Office may promote, expert evidence would prove that Sativex is pharmacologically identical to, for instance, one of the Bedrocan products. There is also now a vast resource of peer-reviewed clinical evidence of medicinal benefits.
There is an horrendously improper judgement (R -v- David King, St Albans Crown Court), where a medicinal user was not allowed even to mention medicinal reasons to a jury on pain of imprisonment for contempt. Your lawyers would need to study this carefully. However, it is so clearly unjust that I do not believe it could be sustained.
Sativex is currently a schedule 1 controlled drug which means it has no medicinal value. As mentioned earlier, the Home Office has dealt with this temporarily by issuing a general licence for it. However, it needs to be re-scheduled and the Advisory Council On the Misuse of Drugs (ACMD) has recommended that it be placed in schedule 4. See here for the full story.
Sativex cannot be re-scheduled under its brand name and the only pharmacologically accurate way of describing it is cannabis. The ACMD left a possible escape route for the Home Office by saying that its “active” ingredients would have to be specified. GW Pharma, the makers of Sativex would say that this means an extract of THC and CBD. However, this is dishonest. Sativex contains all the 60-odd cannabinoids that occur naturally in the plant. There is no other way of describing it accurately than to call it cannabis. If Brokenshire and his cronies try to prolong this deception then they can be challenged by judicial review. The aim here is to ensure that the re-scheduling is accurate and so cannabis becomes a schedule 4 drug. This would then open up all opportunities for cannabis as medicine.
I have no doubt now that medicinal cannabis will be permitted in some form or another in Britain within the near future. We may need to force the government’s hand through litigation or, perhaps Brokenshire will be moved to another department and then the Home Office can “adjust” its position.
At present, it is a monstrous injustice, an evil and obscene scandal, that those who need cannabis as medicine are denied it. The way of politics is that a few years from now it may well all have changed and Brokenshire will be at the Ministry of Silly Walks or somewhere better suited to his talents. However it works out, what I care about is that those in pain and suffering get the relief they need. One day soon, Brokenshire will have to answer to his constituents and later to an even higher power. How he will justify his cruelty and negilgence I don’t really care but I know I wouldn’t want to be in his shoes on judgement day.
Who Is Secretly Working To Keep Pot Illegal – Big Pharma?

This is an extract from an article by Steven Kotler, a science writer who lives in New Mexico. The full article can be read here.
In 2009, the global pharmaceutical market was worth $837 billion—and it’s on track to top $1 trillion by 2014. This is a lot of money to spread around, so when it comes to lobbying efforts, very few have this group’s clout. Mostly, Big Pharma gets what Big Pharma wants. And one thing it wants is for marijuana to remain illegal.
It’s not hard to figure out why. You can’t patent a plant—and that’s a big problem for pharmaceutical companies when it comes to medical marijuana.
Why?
Imagine a wonder drug able to provide much-needed relief from dozens and dozens of conditions. Imagine it’s cheap, easy to grow, easy to dispense, easy to ingest and, over millennia of “product testing,” has produced no fatalities and few side effects—except for the fact that it “reportedly” makes you feel really, really good. That would be quite a drug. Knowing all this, it’s easy to see why the pharmaceutical industry worries about competition from marijuana.
And besides its palliative prowess, researchers consistently find that patients prefer smoking marijuana to taking prescription drugs. In another study run by Reiman, 66 percent of her patients used cannabis as a substitute for prescription drugs; 68 percent used it instead of prescription drugs to treat a chronic condition and 85 percent reported that cannabis had fewer side effects than other medicines.
Early on, the pharmaceutical industry fought back by spending money on anti-pot efforts, but the same NORML investigation that fingered the alcohol and tobacco industries as heavy backers of the Partnership for a Drug-Free America found that Big Pharma was doing so as well. “They were so embarrassed by that revelation” says MAPS founder Rick Doblin, “that they mostly stopped spending money on anti-marijuana lobbying efforts.”
Since then, the pharmaceutical industry has shifted its focus to developing alternatives to medical cannabis, often taking the traditional reductionist approach. Specifically, these days, if a pharmaceutical company wants to turn a plant into a medicine they isolate the most active ingredient and make what’s known as a “single-compound drug.” Morphine, for example, is really just the chemical core of the poppy plant. This too has been tried with marijuana. Out of the 400 chemicals in marijuana, 80 of them belong to a class called “cannabinoids.” Out of those 80 cannabinoids, a number of pharmaceutical companies have tried reducing marijuana to only one: THC. But the results have been unsatisfactory.
“There are certain cases,” says Doblin, “where the single-compound formula works wonders. But it’s just not true in every case. The pharmaceutical industry keeps claiming they’re not worried about medical marijuana because they make a better product, but when you reduce cannabis to just THC, you lose efficacy and gain side effects.”